Dosage ; 100-200mg daily increased to 400mg when required.
Children: 3mg/kg daily in divided dose.
Combinations ; - see below
1. Spironolactone/Frusemide
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Aldactone | Pfizer Global Pharmaceuticals | Surgipharm Ltd | 25mg | 100 | Tablet | per tablet | KES 1,838.74 |
| Aldactone | Pfizer Global Pharmaceuticals | Surgipharm Ltd | 100mg | 10 | Tablet | per tablet | KES 735 |
| Spirolone | Remedica Ltd. | Twokay Chemicals Ltd | 25mg | 28 | Tablet | per tablet | KES 380 |
| Spirolone | Remedica Ltd. | Twokay Chemicals Ltd | 100mg | 28 | Tablet | per tablet | KES 800 |
| Spirolone | Remedica Ltd. | Twokay Chemicals Ltd | 25mg | 50 | Tablet | per tablet | KES 300 |
| Spirolone | Remedica Ltd. | Twokay Chemicals Ltd | 25mg | 500 | Tablet | per tablet | KES 2200 |
| Spirolone | Remedica Ltd. | Twokay Chemicals Ltd | 25mg | 1000 | Tablet | per tablet | KES 4700 |
| Spirolone | Remedica Ltd. | Twokay Chemicals Ltd | 100mg | 100 | Tablet | per tablet | KES 1650 |
| Spironolactone | Actavis (also see Alpharma) | Kulal International Ltd. | 25mg | 28 | Tablet | per tablet | KES 294 |
| Spironolactone | Actavis (also see Alpharma) | Kulal International Ltd. | 50mg | 28 | Tablet | per tablet | KES 379 |
| Spironolactone | Actavis (also see Alpharma) | Kulal International Ltd. | 100mg | 28 | Tablet | per tablet | KES 690 |
| Spironolactone | Actavis (also see Alpharma) | Kulal International Ltd. | 25mg | 28 | Tablet | per tablet | KES 4200 |
| Spironolactone | Actavis (also see Alpharma) | Kulal International Ltd. | 100mg | 100 | Tablet | per tablet | KES 800 |
| Spironolactone More info | |
|---|---|
| Mode Of Action | Aldosterone antagonist |
| Drug Indication | Essential hypertension; primary hyperaldosteronism (diagnosis and maintenance); adjunct therapy in oedema associated with CHF; nephrotic syndrome; hepatic cirrhosis; and treatment of hypokaleamia. Unlabeled use: hirsutism; premenstrual syndrome; short-term treatment of acne vulgaris; precocious puberty. |
| Precautions | Pregnancy; porphyria. |
| Contra-Indications | Allergy to spironolactone; hyperkaleamia; lactation; hepatic or / and renal impairment; addisons disease. |
| Side Effects | Dizziness; headache; drowsiness; ataxia; fatigue; confusion; dry mouth; diarrhoea; thirst; hyperkaleamia; hyponatremia; gynaecomastia; deepening of voice; impotence; irregular menses; post menopausal bleeding; amenorrhea. |
| Dosage | 100-200mg daily increased to 400mg when required. Children: 3mg/kg daily in divided dose. |
| Pregnancy Category | Category B3 |
| Pregnancy Category Description | Drugs which have been taken by only a small number of pregnant women and women of child-bearing age with no any established rise in the frequency of malformations or other direct or indirect detrimental effects on the foetus having been noted. Studies in animals show evidence of an increased occurrence of foetal damage, the significance of which is uncertain in human |
| Drug Category | DRUGS ACTI NG ON THE CARDIO-VASCULAR SYSTEM |
| Drug Sub-Category | Potassium sparing diuretics |
Combinationns ;
| 1. Spironolactone/Frusemide | |
|---|---|
| Mode Of Action | A potassium sparing diuretic (aldosterone antagonist) combined with a loop diuretic . |
| Drug Indication | Hypertension |
| Brand Name | Manufacturer Name | Distributor | Drug Strength | Packaging | Formulation | Formulation Strength | Price |
|---|---|---|---|---|---|---|---|
| Fruselac | Lupin Laboratories | Wessex Pharmaceuticals Limited | 50mg/20mg | 100 | Tablet | per tablet | KES 2,037.00 |